Role of the laboratory in the diagnosis of plasma cell leukemia, about an observation

Authors : Anass Yahyaoui,Hafid Zahid,Nezha Messaoudi

The plasma cell leukemia (PCL) is an extremely uncommon malignant blood disorder with a pejorative prognosis. It is defined by the presence of at least 20% of plasma cells in the peripheral blood or an absolute number of circulating plasma cells greater than 2 G /L. It appears under two variants: secondary PCL that complicates known multiple myeloma and primitive PCL that is immediately leukemic. We report the case of a 56 years old male patient who presented 2 months before his hospitalization diffuse bone pains with asthenia. The CBC revealed an anemia and a leukocytosis. The blood smear objectified 3 G/L circulating plasma cells. The bone marrow exam noted a rich cellularity and a marrow invaded up to 60% by dystrophic plasma cells. The clinical presentation of the plasma cell leukemia, its cytological smear characteristics, immunophenotypical, pathophysiological, therapeutic approach and outcome will be reminded in this article. [Full Article]

Keywords : Plasma cell leukemia , PCL , Myeloma , hyperdiploidy

Published in : International Journal of Medicine & Health Research

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