The Protective Effects of Phyllanthus Emblica in Cyclophosphamide Induced Genotoxicity in Mice

Authors:-Rudrama Devi K, Keshava Rao K

In the present study the antimutagenic effects of Phyllanthus fruit extract (PFE) has been evaluated against cyclophosphamide induced genotoxicity in bone marrow cells of mice. when animals are treated with different doses of phyllanthus fruit extract i.e., 170,340 and 680 mg/kg to mice, the treated group has not showed any significant increase in the percentage of chromosomal aberrations in bone marrow cells of mice at 48 hrs treatment.

A single Intra peritoneal of 50mg/kg of cyclophosphamide induced significant increase in the percentage of chromosomal aberrations in bone marrow cells of mice. However after co administration of three doses of PFE extract there was a dose dependent decrease in the % of micronuclei was observed. When animals were administered with Phyllanthus Fruit Extract PFE 170, 340 & 680 mg/kg/bw orally for seven days and on eightieth day CP (50 mg/kg/bw) was given intraperitonially. For each experimental group control, animals were maintained simultaneously. After the administration of the last dose, the animals were killed and air dried metaphase preparations were made and processed for identification of chromosomal aberrations in somatic cells of mice. In animals treated with single dose of CP, an increase was observed when compared with the values of control group. But when animals primed with PFE + CP group, there was a decrease in the frequency of chromosomal aberrations in somatic cells of mice. Thus the results clearly indicated the protective role of PFE on cyclophosphamide induced genotoxic damage in somatic cells of mice.[Full Article]

KEYWORDS: Cyclophosphamide, genotoxicity, Phyllanthus emblica

Published in :Advances-in-Biology-and-BioMedicine

 

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