Antioxidant activity of polybotanical multinutrient formula. The activity equivalent to mM Trolox (Vitamin E analog) was analyzed using antioxidant assay kit and plotted against PMF concentrations (**p < 0.01, ***p < 0.001 by ANOVA and compared with untreated control sample using Dunnett’s multiple comparison test).

Antioxidant and Anti-inflammatory Effects of a Polybotanical Multinutrient Formula

Authors: Cheppail Ramachandran,Barry J. Wilk, Steven J. Melnick Isaac Eliaz

The novel polybotanical multinutrient formula (PMF) IonShield was analyzed for its antioxidant and anti-inflammatory properties. PMF is a blend of botanical extracts and nutrients designed for cellular protection from free radical damage and oxidative stress such as from environmental, technological, occupational or medical related radiation exposure.

This formula was shown to possess significant dose-dependent antioxidant activity over a broad range of concentrations. PMF was also shown to inhibit lipopolysaccharide (LPS)-induced TNF- production in RAW 264.7 macrophages with complete inhibition at 2000 µg/mL and inhibition of H2O2-induced lipid peroxidation with about 50% reduction at 500 µg/mL. Additionally, both NF-B activation and COX-II activity are also inhibited by PMF with about 40% reduction in COX-II activity at 1000 µg/mL. Demonstration of antioxidant and anti-inflammatory properties suggest potential applications of PMF as a dietary supplement for the amelioration of effects related to oxidative stress and free radical damage.[Full Article]

Key Words: Antioxidant, anti-inflammatory, TNF-α, lipid peroxidation, NF-αB, cyclooxygenase-II 

Published in : [BMR Phytomedicine]