In the present study the antimutagenic effects of Phyllanthus fruit extract (PFE) has been evaluated against cyclophosphamide induced genotoxicity in bone marrow cells of mice. when animals are treated with different doses of phyllanthus fruit extract i.e., 170,340 and 680 mg/kg to mice, the treated group has not showed any significant increase in the percentage of chromosomal aberrations in bone marrow cells of mice at 48 hrs treatment. A single Intra peritoneal of 50mg/kg of cyclophosphamide induced significant increase in the percentage of chromosomal aberrations in bone marrow cells of mice. However after co administration of three doses of PFE extract there was a dose dependent decrease in the % of micronuclei was observed. When animals were administered with Phyllanthus Fruit Extract PFE 170, 340 & 680 mg/kg/bw orally for seven days and on eightieth day CP (50 mg/kg/bw) was given intraperitonially. For each experimental group control, animals were maintained simultaneously. After the administration of the last dose, the animals were killed and air dried metaphase preparations were made and processed for identification of chromosomal aberrations in somatic cells of mice. In animals treated with single dose of CP, an increase was observed when compared with the values of control group. But when animals primed with PFE + CP group, there was a decrease in the frequency of chromosomal aberrations in somatic cells of mice. Thus the results clearly indicated the protective role of PFE on cyclophosphamide induced genotoxic damage in somatic cells of mice.
Background: Caustic ingestion has a wide range of gastrointestinal injuries form mild to severely fatal complications leading to long-term chronic diseases. Since simultaneous rapid use of various methods is difficult or sometimes impossible for determination of need to urgent surgery, initial use of arterial blood gas (ABG) in patients with caustic ingestion may be useful to determine the severity of the injury. Accordingly in this study the ABG data were assessed and compared with endoscopy and laparatomy results to determine the predictive value of ABG. Patients and methods: In this retrospective study 274 consecutive patients with caustic injury attending to Loghman Hospital, Tehran, Iran since 2006 to 2013 were enrolled. Patients included two groups; under surgery and under conservative treatments. In second group, the interval between endoscopy and surgery with arrival time was assessed. Also the initial findings of ABG before treatment, and also the endoscopy and burning grading were determined and compared. Results: The pH and BE alterations were significantly differed between died and alive patients (P=0.001). The endoscopic grading was reversely correlated with HCO3 (P=0.043, r= – 0.274). Also the pH (P=0.041, r= – 0.254) and pCO2 (P=0.006, r= – 0.0342) were reversely correlated to laparatomy grading. Conclusions: Totally, according to the obtained results, it may be concluded that ABG alterations in patients with caustic injuries would result in faster appropriate decision-making for surgery need. For this matter pH less than 7.2 and BE changes more than fifty percent would show the more severe injury that require urgent surgery.
Diabetes is one of the major diseases in India. The present review is attempts to enumerate the list of the plants used for antidiabetic medicine in Andhra Pradesh, India. The herbal medicine have been esteemed source of medicine hence medicinal plants growing concern in current days due to low toxicity and absence of side effects. The World Health Organization (WHO) says about 65-80% of the world’s population of developing countries depends on plants and plant derived compounds for their primary healthcare needs. In the view of above advantages the present review provides profile of 92 plants belongs to 51 families used to treat diabetes described. This clearly shows the importance of medicinal plants in the treatment of diabetes.
Orthodontic treatment for malocclusion correction may involve extraction or non-extraction of specified teeth for esthetic and functional harmony. Antero-posterior and transverse arch dimensional changes following orthodontic treatment has been evaluated using many methods. The present study evaluated the arch dimensional changes after orthodontic treatment in extraction and non-extraction cases using AUTO CAD system with medial and lateral edges of 3rd primary rugae and mesio-incisal tip of the most prominent incisor as the reference points. A total of 100 (Group 1- Upper bicuspid extraction=50; Group 2- Non-extraction=50) orthodontically treated cases were selected in the age range of 19-25 years (Males=50; Females=50). Their pre and post treatment study models were collected and photographed. The photographic data was then digitized and arch dimensional changes were measured using AUTO CAD. The data obtained were subjected to statistical analyses using Paired t-test, Unpaired t-test, Levene’s test and Gain score measurement test. There were significant antero-posterior tooth movements in extraction cases when compared to non extraction cases, a significant reduction in the intermolar width after premolar extractions but minimal changes in the intercanine width showing significance at 5% level. In non-extraction cases, there was no significant arch dimensional changes after orthodontic treatment in both intermolar and intercanine region. Maximum antero-posterior arch dimensional changes can be seen in orthodontically treated bicuspid extraction cases and non extraction cases show minimal changes in the antero-posterior dimensions even after orthodontic treatment. Significant amount of anchorage loss can be seen in upper bicuspid extraction cases when compared to non extraction cases. Reduction in the intermolar width and contraction of maxillary arch occurred in upper bicuspid extraction cases with minimal changes in the intercanine width. Minimal transverse arch dimensional changes occurred in non-extraction cases after orthodontic treatment.
Skin is a protective covering and an attractive feature for both men and women. It forms an important part of personal appearance. But Oily skin can be a challenge. It is usually seen on thicker, larger pored skin and contributes to blemishes. The Parsley leaves extract (juice) is used in this project to study oil control property. The latin name used for parsley (Petroselinum hortense), is formed from two Greek words: “petros” which means “stone” and “selinon” which means “celery. It is important to mention that parsley contains more vitamin C than lemon, orange or any other fruit ie more than 50mg/100g of Parsley. It has abundant quantities of other vitamins and minerals such as: pro vitamin A, vitamin B, vitamin E, vitamin K, beta-carotene, magnesium, phosphorus, iron, manganese, sodium, potassium, sulfur and calcium. Parsley has long been widely used in cosmetics to freshen the face, discoloration, freckles and dark age spots, wrinkles and prevent the occurrence of red spots, strengthen and grow hair. The Cleanser base was selected with the 2% and 4% concentrations of the active which then subjected to its in-vivo study in order to evaluate its oil control property using Sebometer. The 4% concentration of parsley leaf extract was found to be effective oil controlling agent.
Transplantation is the treatment of choice for ESRD patients in ADPKD if there are no contraindications to Surgery or Immunosuppression. Routine pre transplant evaluation for colonic diverticula or intracranial aneurysm is not required in asymptomatic subjects. Nephrectomy is not routinely indicated in ADPKD patient. It is restricted to patients with a history of recurrent cyst infection , recurrent major bleeding ,complicated lithiasis , severe Hypertension ,or massive renal enlargement ,concomitant with renal transplantation When living related donor is considered a screening test should be done to completely eliminate the possibility that the donor will develop ADPKD in future .For potential donors aged older than 30 years ultrasound abdomen is sufficient for screening , whereas in potential donor aged younger than 30 years absence of cyst will not exclude the development of ADPKD. Computed tomography and magnetic resonance imaging may be used for such patients in renal cyst detection. Genetic linkage analysis is a highly sensitive method and is used in donor screening if imaging studies fail.
Infection of the urinary tract is the second commonest site after respiratory tract infection. It is more frequent in women than men. Almost 50% women suffer UTI. In our classical texts, urinary tract infection is described as Mutrakruchcha. The great Acharya Charak has mentioned it in Chikitsa sthana, Trimarmiya adhyay, its 8 types and Basti as a Marma. For the treatment of all types of Mutrakruchcha, Gokshur is mentioned. In samhita period we find reference only for this Laghu Gokshura‛. But for the first time we find in Rajanighantu reference for Brihat Gokshura also called ‚Gokshur dvaya‛. Botanically Laghu Gokkshura is called Tribulus terrestris of Zygophyllaceae family and Brihat gokshura is called Pedalium murex belonging to family Pedaliaceae. These are classified under mishrak varga as ‘Dashmoola’. Gokshur is diuretic, aphrodisiac, tonic and rejuvenating herb with the ability to build lean muscle and strength. Brihat gokshur is mentioned to improve urogenital health. Gokshur possess Madhur rasa, Madhur vipaka and sheet Virya which causes diuresis by increasing Kleda in the body. Due to the visual similarities of the two fruits and their traditional interchanging in Goshukra formulas remarkable difference in there therapeutic properties is not so far studied. So in this study 20 patients complaining of mutrakriccha were assessed by giving laghu Gokshur decoction and brihat gokshur decoction in the dosage of 15 ml twice daily orally. Assessment was done on the basis of sign and symptoms like Mutra daha (burning micturition), Sashula mutrapravruti (painful micturition), Bastishul (suprapubic pain), Mutrapravruti (frequency of micturition), appearance of the urine, Sarakta mutrapravruti (haematuria), Sapuya mutrapravruti (pyuria).
We investigated crystallogenic and initiated properties of gastric mucosa and gastric mucosal homogenates in 12 healthy peoples and 30 patients with ulcer disease (12 patients also have bleeding or perforation or penetration). It is stated, that cocontamination of Helicobacter pylori and Providencia or Morganella combines with high crystallogenic properties of biological fluids. It may be useful for ulcer disease pathogenesis investigation.