Cardiovascular disease is a real public health problem. This study aims to describe the haematological and biochemical perturbations related to this disease in order to ensure a better management of the patients.Thisretrospective and descriptive study covers a period of 20 months at the Laboratory Unit of University Hospital Center Joseph RasetaBefelatanana Antananarivo. All results of haematological and biochemical tests of patients with cardiovascular disease were exploited.Among the 547 patients with cardiovascular diseases, 416 (76.1%) (IC95: 72.2-79.5) had one or more perturbations of the biological tests. As for the biochemical perturbations, 155 patients (28.3%) had high plasma creatinine, 230 patients (42%) had high plasma urea and 84 patients (15.4%) hyperglycemia. The neutrophilic leukocytosis (20.3%), leukopenia (15.7%), normocytic anemia (14.4%), polycythemia (7.5%), thrombocytosis (6.8%) and thrombocytopenia (6.6%) were the most observed haematological perturbations. The elevation of plasma creatinine was significantly associated with normocytic anemia (85.1%) (p = 0.002). Patients with cerebral vascular accidents had neutrophilic leukocytosis in the majority of cases (79.4%) (p = 0.03).A blood count and a complete biochemical test should be prescribed in any patient with cardiovascular disease to better follow the evolution and the prognosis of the disease in order to improve the management of the patient.