Thrombocytosis are conditions frequently encountered in hospitals. This study aims to describe the factors associated with thrombocytosis in hospital patients and out patients. We undertook a case-control study of thrombocytosis between December 01, 2017, and May 31, 2018 in the laboratory of the University Hospital of Befelatanana. Cases are represented by patients who had thrombocytosis in complete blood count. Controls had no thrombocytosis in complete blood count and were matched with cases each day of laboratory analysis. In this study, thrombocytosis decreases with age. Subjects older than 60 years are the least affected (OR, 0.16, 95% CI, 0.05-0.49). Women are less affected than men (OR = 0.89, 95% CI, 0.05-1.59). Thrombocytosis is often discovered accidentally during a health check (OR = 4.78, 95% CI, 1.76-13.21) and frequently affects outpatients. The cases present more abnormalities of blood cells than the controls. These abnormalities are mainly represented by anemia (OR=8.01, 95%CI, 3.55-18.5) and hyperleucocytosis OR=(3.73, 95% CI, 1.69-8.37). Similarly, severe thrombocytosis is significantly associated with leukocytosis (p = 0.02). The blood count should be prescribed for all patients to identify the thrombocytosis that will be treated simultaneously with the disease. Thus, patients will have a good follow-up and their life expectancy will be improved.
Cardiovascular disease is a real public health problem. This study aims to describe the haematological and biochemical perturbations related to this disease in order to ensure a better management of the patients.Thisretrospective and descriptive study covers a period of 20 months at the Laboratory Unit of University Hospital Center Joseph RasetaBefelatanana Antananarivo. All results of haematological and biochemical tests of patients with cardiovascular disease were exploited.Among the 547 patients with cardiovascular diseases, 416 (76.1%) (IC95: 72.2-79.5) had one or more perturbations of the biological tests. As for the biochemical perturbations, 155 patients (28.3%) had high plasma creatinine, 230 patients (42%) had high plasma urea and 84 patients (15.4%) hyperglycemia. The neutrophilic leukocytosis (20.3%), leukopenia (15.7%), normocytic anemia (14.4%), polycythemia (7.5%), thrombocytosis (6.8%) and thrombocytopenia (6.6%) were the most observed haematological perturbations. The elevation of plasma creatinine was significantly associated with normocytic anemia (85.1%) (p = 0.002). Patients with cerebral vascular accidents had neutrophilic leukocytosis in the majority of cases (79.4%) (p = 0.03).A blood count and a complete biochemical test should be prescribed in any patient with cardiovascular disease to better follow the evolution and the prognosis of the disease in order to improve the management of the patient.