The transformation chronic lymphocytic leukemia (CLL) into Richter syndrome represents aggressive clinical evolution of CLL. In most cases, this transformation corresponds to diffuse large B-cell lymphoma, but in very rare cases it can lead to Hodgkin’s Disease Variant of Richter’s Syndrome. We report a case of CLL transformed into Hodgkin’s disease type of Richter’s Syndrome in a 70-year-old male patient. Microscopic examination showed the presence of large tumor cells with the morphological and immunophenotypic features in favor of classical Hodgkin and Reed-Sternberg cells. The transformation of CLL into Hodgkin’s disease poses a problem of histogenetic diagnosis. According to the literature, the clonal relationship between CLL and Hodgkin’s disease is likely with prognostic value. Two forms of Hodgkin’s Disease Variant of Richter’s Syndrome are described with different prognoses: a form that corresponds to a true transformation of the CLL into a Hodgkin’s disease, a poor prognosis and a second form that corresponds to the co-existence of CLL and Hodgkin’s disease with better prognosis.
Introduction: The purpose of our study is presenting new national statistics of phenotypic prevalence Rhesus systems (Rh) and Kell using a new sample of blood donors.
Materials and Methods:This study was conducted in the blood transfusion department of the Avicenna military hospital of Marrakech on a sample of 1286 donors collected between 01/01/2015 and 31/12/2015. This is a military population dominated by men (99%), and composed of young people aged from 18 to 45 years. The samples have been collected in EDTA tubes. The tests were performed on gel-card or on opaline plate at the laboratory temperature. Reagents used are monoclonal antibodies from Society Bio-Rad.
Results : Our results shows a clear predominance of the Rh1 (D) positive (89.81%) compared to Rh-1 (d) negative (10.19%). CcDee was the most common phenotype (38.95%) followed by ccDee (18.91%) CCDee, ccDEe, ccdee and CcDEe. The ccDEE, CCDEe and ccdEe phenotypes are the minority phenotypes. For the Kell system, the predominance of Kell-1 subjects was clearly observed at a frequency of 93%. The Rh D allele was the most prevalent (68.08%) among RH blood type alleles while and the Kell-1 (96.44%) was the frequent among the alleles of Kell blood group system.
Discussion and Conclusion : our results compared to previous national and international studies show that Morocco is in an intermediate situation among the Caucasoid and negroids populations.
Introduction: the purpose of our work was to present new national statistical of phenotypic and genotypic prevalence of ABO and Rhesus (D) blood groups using a new sample.
Materials and Methods: This study was carried out in the department of blood transfusion center of the Avicenna Military hospital Marrakech on a sample of 8077 young recruits between 1/1/2015and 12/31/2015. This is a military population from different Moroccan region, composed by 98% of men and 2% of women, whose ages range between 18 and 21 years. Results: The blood group “O” was found in approximately half of the samples (49,01%), the rate of group A (31.47%) was two times higher than that of group B (15.15%), group AB was the least frequent (4.35%). We note a clear predominance of the Rh positive subjects (89.86%) compared to the Rh negative subjects (10.13%) in our Moroccan population. Regarding the frequency of the genotypes of our population we have the following results: O allele was the most common, its prevalence was 89.82%, the A allele was in second position with a frequency of 19, 90 %, allele B was the least frequent (10, 28%). The allele D (RH1) (68.17%) was dominant over the d (RH-1) allele (31.82%).Discussion and conclusion: Our results are compared to previous similar studies carried out in Morocco and in other countries. These results are identical to those found in Mediterranean countries and shows that Morocco is in an intermediate situation between the countries of Europe and those of Sub-Saharan Africa.