The Jaisalmer district a part of Thar Desert is very rich in medicinal plant wealth. These medicinal plants have been used by local people and tribal communities since long time in herbal and folk remedies. Kalbelia, Nats, Bhils, Raika, Bhopas, Banjara, Gadolia-Lohar, Garasia and Saharia tribal communities of this district have a rich knowledge of plants based traditional medicines. Fifteen ethnomedicinal plants like Abrus precatorius Linn., Aerva persica Burm.f., Argemone mexicana Linn., Calligonum polygonoides Linn., Chenopodium album Linn. Cleome viscosa Linn., Commiphora wightii Arnott., Corchorus depressus Linn., Cucumis melo Linn., Euphorbia hirta Linn., Fagonia indica Burm., Grewia tenax Forsk., Salvadora oleoides Decne., Solanum nigrum Linn. and Ziziphus nummularia Burm. have been selected for this research work. The present investigation is aimed to create awareness about the ethnomedicinal value of the plants and their uses to draw the attention of pharmacologists, phytochemists and pharmaceuticals.