Croton spp. has been used medicinally in the treatment of a variety of ailments, which include cancer, constipation, and diabetes. Various parts of the plant are used in Nigeria as antimicrobial, arbortifacient, anti-inflammatory and anti-tumorigenic agents. Dried leaves of Croton penduliflorus (Hutch) was powdered, extracted and concentrated, and the aqueous fraction partitioned into dichloromethane, ethylacetate and n-butanol. The following parametes were determined, ABTS and DPPH radical scavenging activity, Free Radical Antioxidant Power, total antioxidant capacity, total phenolic and total flavonoid contents. The aqueous and dichloromethane fractions gave the highest yields, and the crude extracts exhibited a high amount of total phenol and total flavonoids. The crude extract and dichloromethane fractions showed a high scavenging activity for ABTS and DPPH, while the crude extract and its fractions demonstrate significant radical scavenging ability and antioxidant capacity which were due to the presence of phenols and flavonoids.