From time immemorial, people valued fruits as a good source of nutrition, but only the edible portions were used and the outer peels were discarded as wastes. Many of the fruits and vegetables skins are still thrown in the garbage or fed to livestock. The peels of fruits and vegetables and their by-products are formed in great amounts during industrial processing, and cause serious concern, since they accumulate as wastes and pollute the environment. Hence, such wastes need to be managed and/or utilized. On the other hand, they are very rich in bioactive components, which are considered to have a therapeutic value. Hence, efforts have been made to find ways to reuse fruits and vegetables wastes. Using this agro waste therapeutically is a new idea which is slowly gaining popularity. They are high value products and their recovery will be economically attractive. These are novel, natural, eco friendly and economic sources of antimicrobials, which can be used in the prevention of diseases caused by pathogenic microbes and also reduce pollution. Hence this pilot study was undertaken to screen the peels of five commonly used fruits for antibacterial activity against a few clinical strains. The results indicate that the peels can be used and further investigated as sources of antimicrobials.