Objective : To assess and compare plasma fibrinogen and fibrin degradation product level in preeclamptic and normotensive patients.
Materials and Methods: This is a cross sectional study carried out in the Department of Obstetrics and Gynaecology, SMS Medical College and associated Hospitals, Jaipur (Rajasthan) from April 2014 to March 2016 for a period of 2 year. The study population included 25 women with preeclampsia (cases) and 25 normotensive pregnant women (controls) in their third trimester. Cases were further grouped into mild preeclampsia (n=18), severe preeclampsia (n=4) and eclampsia (3) according to severity of preeclampsia. Plasma fibrinogen and FDP levels were estimated. Results of both groups were compared to evaluate the association of plasma fibrinogen and FDP with preeelampsia and its severity.
Results: The mean plasma fibrinogen level was 528.96 ± 93.25 mg/dl in preeclamptics as compared to control 365.48 ± 109.85 mg/dl, which was statistically significant (p=0.001). The mean values of plasma FDP in cases and controls were respectively 8.52±12.50 and 5.72±1.96 µg/ml (p = 0.000). Elevation in fibrinogen and FDP levels were more for severe preeclampsia and eclampsia group than mild preeclampsia group.
Conclusion : Preeclampsia is associated with high fibrinogen and FDP levels as compared to normal pregnancies. The levels of plasma fibrinogen and FDP increase as does the severity of preeclampsia.