The pathogenesis of Zika virus infection is not well known and the effects on the structure of the placental villi require to be investigated. Is our proposal to describe the histopathological changes that occur in the placental villi provoked by Zika virus. The pacient of 38 years old was infected during the third trimester of pregnancy a week before parturition manifesting symptoms of infection by Zika. Light and scanning electron microscopy were used. Numerous stem villi are suffering degenerative changes with collapsed vessels. A conglomerate of syncytial knots and degenerated peripheric surface can be seen. Immature intermediate villi suffers fibrinoid deposition with macrophagues together in Hoffbauer channels. Necrosis of the syncytium and stromal fibrosis were noted on the placental villi. Koylocytic cell,destroyed villi,damage in the wall of vessels and mature intermediate villi with scarcity of terminal villi were found. Bad development of the ramifications of the placental villi and regions of lysis in stromal region were located. Thrombus and edema could not be seen. The placental villous tree has been found suffering severe degenerative changes and bad development indicating a destructive effect on the structure of the placenta that could to explain the cytopathic effect provoked by zika virus.
Purpose Hyperbilirubinemia is the most common medical problem in newborn infants. Early discharge is recommended but hospital readmission is a cause of concern among clinicians ,and early discharge of neonates is recommended. This inturn carries a risk of delayed recognition of significant hyperbilirubinemia.A cross-sectional analytical study was done primarily to evaluate the predictive value of cord bilirubin level for identifying term and near term neonates for subsequent hyperbilirubinemia.
Materials & Methods Cord bilirubin levels at birth and subsequently serum bilirubin levels at 72 hours were assessed in 100 neonates. The cut off value was estimated beyond which there was significant hyperbilirubinemia.
Result The cut off value of cord bilirubin >2.02 mg/dl had sensitivity and specificity of 87.5% and 70.8% respectively with positive predictive value of 0.39 and negative predictive value of 0.965 for subsequent hyperbilirubinemia.
Conclusion The cut-off value of cord bilirubin level estimated is 2.02 mg/dl can be used to predict significant neonatal hyperbilirubinemia.