Natural products, such as plants extract, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug discoveries because of the availability of chemical diversity. Bioactive compounds are secondary metabolites in all plant cells. Leaves are one of the highest accumulatory plant parts for such compounds. Manilkara zapota belongs to the family Sapotaceae. The leaves are antibiotic, astringent and febrifuge. Averrhoa carambola belongs to family Oxalidaceae. The leaves are used for chicken pox, ringworm and headache and a decoction of leaves is used to arrest vomiting. Here we are reporting the phytochemical constituents and Antimicrobial Activity of three different extracts (Aqueous, Ethyl Acetate and Petroleum ether) from leaves of Manilkara zapota and Averrhoa carambola against pathogenic Fungi and Yeast. Preliminary screening of Manilkara zapota revealed the presence of Alkaloids, Flavonoids, Quinones and Glycosides and that of Averrhoa carambola shows presence of Alkaloids, Flavonoids, Glycosides and Quinones. Antifungal activity was evaluated by agar well diffusion method. The two plant leaves extract showed different degree of activity against the organisms being investigated. The Ethyl Acetate extract of Averrhoa carambola was found to be most effective whereas Petroleum ether extract of Manilkara zapota was most effective against pathogenic fungi and yeast.